3-hydroxydecanoyl-(acyl-carrier-protein) dehydratase

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3-hydroxydecanoyl-(acyl-carrier-protein) dehydratase
Identifiers
EC number 4.2.1.60
CAS number 9030-79-9
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

3-hydroxydecanoyl-(acyl-carrier-protein) dehydratase (EC 4.2.1.60, D-3-hydroxydecanoyl-[acyl-carrier protein] dehydratase, 3-hydroxydecanoyl-acyl carrier protein dehydrase, 3-hydroxydecanoyl-acyl carrier protein dehydratase, beta-hydroxydecanoyl thioester dehydrase, beta-hydroxydecanoate dehydrase, beta-hydroxydecanoyl thiol ester dehydrase, FabA, beta-hydroxyacyl-acyl carrier protein dehydratase, HDDase, beta-hydroxyacyl-ACP dehydrase, (3R)-3-hydroxydecanoyl-[acyl-carrier-protein] hydro-lyase) is an enzyme with systematic name (3R)-3-hydroxydecanoyl-(acyl-carrier protein) hydro-lyase.[1][2][3][4][5][6][7] This enzyme catalyses the following chemical reaction

(1) a (3R)-3-hydroxydecanoyl-[acyl-carrier protein] a trans-dec-2-enoyl-[acyl-carrier protein] + H2O
(2) a (3R)-3-hydroxydecanoyl-[acyl-carrier protein] a cis-dec-3-enoyl-[acyl-carrier protein] + H2O

This enzyme is specific for C10 chain length.

References[edit]

  1. ^ Kass, L.R.; Brock, D.J.H.; Bloch, K. (1967). "β-Hydroxydecanoyl thioester dehydrase. I. Purification and properties". J. Biol. Chem. 242 (19): 4418–4431. PMID 4863739. 
  2. ^ Brock, D.J.H.; Kass, L.R.; Bloch, K. (1967). "β-Hydroxydecanoyl thioester dehydrase. II. Mode of action". J. Biol. Chem. 242 (19): 4432–4440. PMID 4863740. 
  3. ^ Sharma, A.; Henderson, B.S.; Schwab, J.M.; Smith, J.L. (1990). "Crystallization and preliminary X-ray analysis of β-hydroxydecanoyl thiol ester dehydrase from Escherichia coli". J. Biol. Chem. 265 (9): 5110–5112. PMID 2180957. 
  4. ^ Magnuson, K.; Jackowski, S.; Rock, C.O.; Cronan, J.E. Jr. (1993). "Regulation of fatty acid biosynthesis in Escherichia coli". Microbiol. Rev. 57 (3): 522–542. PMC 372925Freely accessible. PMID 8246839. 
  5. ^ Bloch, K. (1969). "Enzymatic synthesis of monounsaturated fatty acids". Acc. Chem. Res. 2: 193–202. doi:10.1021/ar50019a001. 
  6. ^ Wang, H.; Cronan, J.E. (2004). "Functional replacement of the FabA and FabB proteins of Escherichia coli fatty acid synthesis by Enterococcus faecalis FabZ and FabF homologues". J. Biol. Chem. 279: 34489–34495. doi:10.1074/jbc.M403874200. PMID 15194690. 
  7. ^ Cronan, J.E. Jr.; Rock, C.O. (1996). "Biosynthesis of membrane lipids". In Neidhardt, F.C. Escherichia coli and Salmonella: Cellular and Molecular Biology. 1 (2nd ed.). Washington, DC: ASM Press. pp. 612–636. 

External links[edit]