Protostadienol synthase

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Protostadienol synthase
Identifiers
EC number 5.4.99.32
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

Protostadienol synthase (EC 5.4.99.32, PdsA, (S)-2,3-epoxysqualene mutase [cyclizing, (17Z)-protosta-17(20),24-dien-3beta-ol-forming]) is an enzyme with systematic name (3S)-2,3-epoxy-2,3-dihydrosqualene mutase (cyclizing, (17Z)-protosta-17(20),24-dien-3beta-ol-forming).[1] This enzyme catalyses the following chemical reaction

(3S)-2,3-epoxy-2,3-dihydrosqualene (17Z)-protosta-17(20),24-dien-3beta-ol

(17Z)-Protosta-17(20),24-dien-3beta-ol is a precursor of the steroidal antibiotic helvolic acid.

References[edit]

  1. ^ Lodeiro, S.; Xiong, Q.; Wilson, W.K.; Ivanova, Y.; Smith, M.L.; May, G.S.; Matsuda, S.P. (2009). "Protostadienol biosynthesis and metabolism in the pathogenic fungus Aspergillus fumigatus". Org. Lett. 11: 1241–1244. doi:10.1021/ol802696a. PMID 19216560. 

External links[edit]