Marneral synthase

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Marneral synthase
Identifiers
EC number 5.4.99.53
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

Marneral synthase (EC 5.4.99.53) is an enzyme with systematic name (3S)-2,3-epoxy-2,3-dihydrosqualene mutase (cyclizing, marneral-forming).[1] This enzyme catalyses the following chemical reaction

(3S)-2,3-epoxy-2,3-dihydrosqualene marneral

Marneral is a triterpenoid formed by Grob fragmentation of the A ring of 2,3-epoxy-2,3-dihydrosqualene during cyclization, this aldehyde gains its name from its structural similarity to a class triterpenes commonly found in members of the Iridaceae, originally identified by Dr. Franz-Josef Marner.[2]

This enzyme is a member of a metabolic gene cluster along with two other cytochrome P450s.[3]

References[edit]

  1. ^ Xiong, Quanbo; Wilson, William K.; Matsuda, Seiichi P. T. (2006-02-13). "An Arabidopsis oxidosqualene cyclase catalyzes iridal skeleton formation by Grob fragmentation". Angewandte Chemie (International Ed. in English). 45 (8): 1285–1288. doi:10.1002/anie.200503420. ISSN 1433-7851. PMID 16425307. 
  2. ^ Xiong, Quanbo; Wilson, William K.; Matsuda, Seiichi P. T. (2006-02-13). "An Arabidopsis oxidosqualene cyclase catalyzes iridal skeleton formation by Grob fragmentation". Angewandte Chemie (International Ed. in English). 45 (8): 1285–1288. doi:10.1002/anie.200503420. ISSN 1433-7851. PMID 16425307. 
  3. ^ Field, Ben; Fiston-Lavier, Anna-Sophie; Kemen, Ariane; Geisler, Katrin; Quesneville, Hadi; Osbourn, Anne E. (2011-09-20). "Formation of plant metabolic gene clusters within dynamic chromosomal regions". Proceedings of the National Academy of Sciences. 108 (38): 16116–16121. doi:10.1073/pnas.1109273108. ISSN 0027-8424. PMC 3179108Freely accessible. PMID 21876149. 

External links[edit]