Branched-chain-2-oxoacid decarboxylase

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branched-chain-2-oxoacid decarboxylase
Identifiers
EC number 4.1.1.72
CAS number 63653-19-0
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / QuickGO

In enzymology, a branched-chain-2-oxoacid decarboxylase (EC 4.1.1.72) is an enzyme that catalyzes the chemical reaction

(3S)-3-methyl-2-oxopentanoate 2-methylbutanal + CO2

Hence, this enzyme has one substrate, (3S)-3-methyl-2-oxopentanoate, and two products, 2-methylbutanal and CO2.

This enzyme belongs to the family of lyases, specifically the carboxy-lyases, which cleave carbon-carbon bonds. The systematic name of this enzyme class is (3S)-3-methyl-2-oxopentanoate carboxy-lyase (2-methylbutanal-forming). Other names in common use include branched-chain oxo acid decarboxylase, branched-chain alpha-keto acid decarboxylase, branched-chain keto acid decarboxylase, BCKA, and (3S)-3-methyl-2-oxopentanoate carboxy-lyase.

References[edit]

  • Oku H, Kaneda T (1988). "Biosynthesis of branched-chain fatty acids in Bacillus subtilis. A decarboxylase is essential for branched-chain fatty acid synthetase". J. Biol. Chem. 263 (34): 18386–96. PMID 3142877.