5-phosphonooxy-L-lysine phospho-lyase

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5-phosphonooxy-L-lysine phospho-lyase
Identifiers
EC number 4.2.3.134
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

5-phosphonooxy-L-lysine phospho-lyase (EC 4.2.3.134, 5-phosphohydroxy-L-lysine ammoniophospholyase, AGXT2L2 (gene)) is an enzyme with systematic name (5R)-5-phosphonooxy-L-lysine phosphate-lyase (deaminating; (S)-2-amino-6-oxohexanoate-forming).[1][2] This enzyme catalyses the following chemical reaction

(5R)-5-phosphonooxy-L-lysine + H2O (S)-2-amino-6-oxohexanoate + NH3 + phosphate

This enzyme is a pyridoxal-phosphate protein.

References[edit]

  1. ^ Tsai, C.H.; Henderson, L.M. (1974). "Degradation of O-phosphohydroxylysine by rat liver. Purification of the phospho-lyase". J. Biol. Chem. 249: 5784–5789. PMID 4412716. 
  2. ^ Veiga-da-Cunha, M.; Hadi, F.; Balligand, T.; Stroobant, V.; Van Schaftingen, E. (2012). "Molecular identification of hydroxylysine kinase and of ammoniophospholyases acting on 5-phosphohydroxy-L-lysine and phosphoethanolamine". J. Biol. Chem. 287: 7246–7255. doi:10.1074/jbc.m111.323485. PMC 3293546Freely accessible. PMID 22241472. 

External links[edit]