Trans-2,3-dihydro-3-hydroxyanthranilate isomerase

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Trans-2,3-dihydro-3-hydroxyanthranilate isomerase
Identifiers
EC number 5.3.3.17
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

Trans-2,3-dihydro-3-hydroxyanthranilate isomerase (EC 5.3.3.17, phzF (gene)) is an enzyme with systematic name (5S,6S)-6-amino-5-hydroxycyclohexane-1,3-diene-1-carboxyate isomerase.[1][2][3][4][5] This enzyme catalyses the following chemical reaction

(5S,6S)-6-amino-5-hydroxycyclohexane-1,3-diene-1-carboxyate (1R,6S)-6-amino-5-oxocyclohex-2-ene-1-carboxylate

The enzyme is involved in phenazine biosynthesis.

References[edit]

  1. ^ Parsons, J.F.; Song, F.; Parsons, L.; Calabrese, K.; Eisenstein, E.; Ladner, J.E. (2004). "Structure and function of the phenazine biosynthesis protein PhzF from Pseudomonas fluorescens 2-79". Biochemistry. 43: 12427–12435. doi:10.1021/bi049059z. PMID 15449932. 
  2. ^ Blankenfeldt, W.; Kuzin, A.P.; Skarina, T.; Korniyenko, Y.; Tong, L.; Bayer, P.; Janning, P.; Thomashow, L.S.; Mavrodi, D.V. (2004). "Structure and function of the phenazine biosynthetic protein PhzF from Pseudomonas fluorescens". Proc. Natl. Acad. Sci. USA. 101: 16431–16436. doi:10.1073/pnas.0407371101. PMC 534541Freely accessible. PMID 15545603. 
  3. ^ Parsons, J.F.; Calabrese, K.; Eisenstein, E.; Ladner, J.E. (2004). "Structure of the phenazine biosynthesis enzyme PhzG". Acta Crystallogr. D. 60: 2110–2113. doi:10.1107/s0907444904022474. PMID 15502343. 
  4. ^ Mavrodi, D.V.; Bleimling, N.; Thomashow, L.S.; Blankenfeldt, W. (2004). "The purification, crystallization and preliminary structural characterization of PhzF, a key enzyme in the phenazine-biosynthesis pathway from Pseudomonas fluorescens 2-79". Acta Crystallogr. D. 60: 184–186. doi:10.1107/s090744490302571x. PMID 14684924. 
  5. ^ Ahuja, E.G.; Janning, P.; Mentel, M.; Graebsch, A.; Breinbauer, R.; Hiller, W.; Costisella, B.; Thomashow, L.S.; Mavrodi, D.V.; Blankenfeldt, W. (2008). "PhzA/B catalyzes the formation of the tricycle in phenazine biosynthesis". J. Am. Chem. Soc. 130: 17053–17061. doi:10.1021/ja806325k. PMID 19053436. 

External links[edit]