(6-4)DNA photolyase

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(6-4)DNA photolyase
Identifiers
EC number 4.1.99.13
CAS number 37290-70-3
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

(6-4)DNA photolyase (EC 4.1.99.13, DNA photolyase, H64PRH, NF-10, phr (6-4), PL-(6-4), OtCPF1, (6-4) PHR, At64PHR) is an enzyme with systematic name (6-4) photoproduct pyrimidine-lyase.[1][2] This enzyme catalyses the following chemical reaction

(6-4) photoproduct (in DNA) 2 pyrimidine residues (in DNA)

This enzyme is a flavoprotein.

References[edit]

  1. ^ Hitomi, K.; DiTacchio, L.; Arvai, A.S.; Yamamoto, J.; Kim, S.T.; Todo, T.; Tainer, J.A.; Iwai, S.; Panda, S.; Getzoff, E.D. (2009). "Functional motifs in the (6-4) photolyase crystal structure make a comparative framework for DNA repair photolyases and clock cryptochromes". Proc. Natl. Acad. Sci. USA. 106: 6962–6967. doi:10.1073/pnas.0809180106. PMC 2678464Freely accessible. PMID 19359474. 
  2. ^ Schleicher, E.; Hitomi, K.; Kay, C.W.; Getzoff, E.D.; Todo, T.; Weber, S. (2007). "Electron nuclear double resonance differentiates complementary roles for active site histidines in (6-4) photolyase". J. Biol. Chem. 282: 4738–4747. doi:10.1074/jbc.m604734200. PMID 17164245. 

External links[edit]