8-Hydroxygeraniol dehydrogenase

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8-Hydroxygeraniol dehydrogenase
Identifiers
EC number 1.1.1.324
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

8-hydroxygeraniol dehydrogenase (EC 1.1.1.324, 8-hydroxygeraniol oxidoreductase, CYP76B10, G10H, CrG10H, SmG10H, acyclic monoterpene primary alcohol:NADP+ oxidoreductase) is an enzyme with systematic name (6E)-8-hydroxygeraniol:NADP+ oxidoreductase.[1][2] This enzyme catalyses the following chemical reaction

(6E)-8-hydroxygeraniol + 2 NADP+ (6E)-8-oxogeranial + 2 NADPH + 2 H+ (overall reaction)
(1a) (6E)-8-hydroxygeraniol + NADP+ (6E)-8-hydroxygeranial + NADPH + H+
(1b) (6E)-8-hydroxygeraniol + NADP+ (6E)-8-oxogeraniol + NADPH + H+
(1c) (6E)-8-hydroxygeranial + NADP+ (6E)-8-oxogeranial + NADPH + H+
(1d) (6E)-8-oxogeraniol + NADP+ (6E)-8-oxogeranial + NADPH + H+

This enzyme contains Zn2+. It catalyses the oxidation of (6E)-8-hydroxygeraniol to (6E)-8-oxogeranial via either (6E)-8-hydroxygeranial or (6E)-8-oxogeraniol.

References[edit]

  1. ^ Ikeda, H.; Esaki, N.; Nakai, S.; Hashimoto, K.; Uesato, S.; Soda, K.; Fujita, T. (1991). "Acyclic monoterpene primary alcohol:NADP+ oxidoreductase of Rauwolfia serpentina cells: the key enzyme in biosynthesis of monoterpene alcohols". J. Biochem. 109 (2): 341–347. PMID 1864846. 
  2. ^ Hallahan, D.L.; West, J.M.; Wallsgrove, R.M.; Smiley, D.W.; Dawson, G.W.; Pickett, J.A.; Hamilton, J.G. (1995). "Purification and characterization of an acyclic monoterpene primary alcohol:NADP+ oxidoreductase from catmint (Nepeta racemosa)". Arch. Biochem. Biophys. 318 (1): 105–112. doi:10.1006/abbi.1995.1210. PMID 7726550. 

External links[edit]