ADP-dependent NAD(P)H-hydrate dehydratase

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ADP-dependent NAD(P)H-hydrate dehydratase
Identifiers
EC number 4.2.1.136
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

ADP-dependent NAD(P)H-hydrate dehydratase (EC 4.2.1.136, (6S)-beta-6-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine-dinucleotide hydro-lyase (ADP-hydrolysing), (6S)-6-beta-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine-dinucleotide hydro-lyase (ADP-hydrolysing, NADH-forming)) is an enzyme with systematic name (6S)-6beta-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine-dinucleotide hydro-lyase (ADP-hydrolysing; NADH-forming).[1] This enzyme catalyses the following chemical reaction

(1) ADP + (6S)-6beta-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine dinucleotide AMP + phosphate + NADH
(2) ADP + (6S)-6beta-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine dinucleotide phosphate AMP + phosphate + NADPH

This enzyme acts equally well on hydrated NADH and hydrated NADPH.

References[edit]

  1. ^ Marbaix, A.Y.; Noel, G.; Detroux, A.M.; Vertommen, D.; Van Schaftingen, E.; Linster, C.L. (2011). "Extremely conserved ATP- or ADP-dependent enzymatic system for nicotinamide nucleotide repair". J. Biol. Chem. 286: 41246–41252. doi:10.1074/jbc.c111.310847. PMC 3308837Freely accessible. PMID 21994945. 

External links[edit]