9,12-octadecadienoate 8-hydroperoxide 8S-isomerase

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9,12-octadecadienoate 8-hydroperoxide 8S-isomerase
Identifiers
EC number 5.4.4.6
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

9,12-octadecadienoate 8-hydroperoxide 8S-isomerase (EC 5.4.4.6, 8-hydroperoxide isomerase, (8R,9Z,12Z)-8-hydroperoxy-9,12-octadecadienoate mutase ((7S,8S,9Z,12Z)-7,8-dihydroxy-9,12-octadecadienoate-forming)) is an enzyme with systematic name (8R,9Z,12Z)-8-hydroperoxyoctadeca-9,12-dienoate hydroxymutase ((7S,8S,9Z,12Z)-7,8-dihydroxyoctadeca-9,12-dienoate-forming).[1][2][3] This enzyme catalyses the following chemical reaction

(8R,9Z,12Z)-8-hydroperoxyoctadeca-9,12-dienoate (7S,8S,9Z,12Z)-7,8-dihydroxyoctadeca-9,12-dienoate

This enzyme contains heme.

References[edit]

  1. ^ Hamberg, M.; Zhang, L.-Y.; Brodowsky, I.D.; Oliw, E.H. (1994). "Sequential oxygenation of linoleic acid in the fungus Gaeumannomyces graminis: stereochemistry of dioxygenase and hydroperoxide isomerase reactions". Arch. Biochem. Biophys. 309: 77–80. doi:10.1006/abbi.1994.1087. PMID 8117115. 
  2. ^ Su, C.; Sahlin, M.; Oliw, E.H. (1998). "A protein radical and ferryl intermediates are generated by linoleate diol synthase, a ferric hemeprotein with dioxygenase and hydroperoxide isomerase activities". J. Biol. Chem. 273: 20744–20751. doi:10.1074/jbc.273.33.20744. PMID 9694817. 
  3. ^ Su, C.; Oliw, E.H. (1996). "Purification and characterization of linoleate 8-dioxygenase from the fungus Gaeumannomyces graminis as a novel hemoprotein". J. Biol. Chem. 271: 14112–14118. doi:10.1074/jbc.271.24.14112. PMID 8662736. 

External links[edit]