Allene oxide cyclase

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allene-oxide cyclase
Identifiers
EC number 5.3.99.6
CAS number 118390-59-3
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / QuickGO

In enzymology, an allene-oxide cyclase (EC 5.3.99.6) is an enzyme that catalyzes the chemical reaction

(9Z)-(13S)-12,13-epoxyoctadeca-9,11,15-trienoate (15Z)-12-oxophyto-10,15-dienoate

Hence, this enzyme has one substrate, (9Z)-(13S)-12,13-epoxyoctadeca-9,11,15-trienoate, and one product, (15Z)-12-oxophyto-10,15-dienoate.

This enzyme belongs to the family of isomerases, specifically a class of other intramolecular oxidoreductases, the systematic name of this enzyme class is (9Z)-(13S)-12,13-epoxyoctadeca-9,11,15-trienoate isomerase (cyclizing).

Structural studies[edit]

As of late 2007, 6 structures have been solved for this class of enzymes, with PDB accession codes 1Z8K, 1ZVC, 2BRJ, 2DIO, 2GIN, and 2Q4I.

References[edit]

  • Hamberg M (1988). "Biosynthesis of 12-oxo-10,15(Z)-phytodienoic acid: identification of an allene oxide cyclase". Biochem. Biophys. Res. Commun. 156 (1): 543–50. doi:10.1016/S0006-291X(88)80876-3. PMID 3178850.