2-methylisoborneol synthase

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2-methylisoborneol synthase
Identifiers
EC number 4.2.3.118
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

2-methylisoborneol synthase (EC 4.2.3.118, sco7700, 2-MIB cyclase, MIB synthase, MIBS) is an enzyme with systematic name (E)-2-methylgeranyl-diphosphate diphosphate-lyase (cyclizing, 2-methylisoborneol-forming).[1][2][3] This enzyme catalyses the following chemical reaction

(E)-2-methylgeranyl diphosphate + H2O 2-methylisoborneol + diphosphate

The product, 2-methylisoborneol, is a characteristic odiferous compound with a musty smell produced by soil microorganisms.

References[edit]

  1. ^ Wang, C.M.; Cane, D.E. (2008). "Biochemistry and molecular genetics of the biosynthesis of the earthy odorant methylisoborneol in Streptomyces coelicolor". J. Am. Chem. Soc. 130: 8908–8909. doi:10.1021/ja803639g. PMC 3023297Freely accessible. PMID 18563898. 
  2. ^ Komatsu, M.; Tsuda, M.; Omura, S.; Oikawa, H.; Ikeda, H. (2008). "Identification and functional analysis of genes controlling biosynthesis of 2-methylisoborneol". Proc. Natl. Acad. Sci. USA. 105: 7422–7427. doi:10.1073/pnas.0802312105. PMC 2387273Freely accessible. PMID 18492804. 
  3. ^ Giglio, S.; Chou, W.K.; Ikeda, H.; Cane, D.E.; Monis, P.T. (2011). "Biosynthesis of 2-methylisoborneol in cyanobacteria". Environ. Sci. Technol. 45: 992–998. doi:10.1021/es102992p. PMC 3699865Freely accessible. PMID 21174459. 

External links[edit]