(Histone-H3)-lysine-36 demethylase

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(Histone-H3)-lysine-36 demethylase
Identifiers
EC number 1.14.11.27
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

(Histone-H3)-lysine-36 demethylase (EC 1.14.11.27, JHDM1A, JmjC domain-containing histone demethylase 1A, H3-K36-specific demethylase, histone-lysine (H3-K36) demethylase, histone demethylase, protein-6-N,6-N-dimethyl-L-lysine,2-oxoglutarate:oxygen oxidoreductase) is an enzyme with systematic name protein-N6,N6-dimethyl-L-lysine,2-oxoglutarate:oxygen oxidoreductase.[1] This enzyme catalyses the following chemical reaction

protein N6,N6-dimethyl-L-lysine + 2 2-oxoglutarate + 2 O2 protein L-lysine + 2 succinate + 2 formaldehyde + 2 CO2 (overall reaction)
(1a) protein N6,N6-dimethyl-L-lysine + 2-oxoglutarate + O2 protein N6-methyl-L-lysine + succinate + formaldehyde + CO2
(1b) protein N6-methyl-L-lysine + 2-oxoglutarate + O2 protein L-lysine + succinate + formaldehyde + CO2

(Histone-H3)-lysine-36 demethylase contains iron(II).

References[edit]

  1. ^ Tsukada, Y.; Fang, J.; Erdjument-Bromage, H.; Warren, M.E.; Borchers, C.H.; Tempst, P.; Zhang, Y. (2006). "Histone demethylation by a family of JmjC domain-containing proteins". Nature. 439: 811–816. doi:10.1038/nature04433. PMID 16362057. 

External links[edit]