(KDO)2-lipid IVA (2-8) 3-deoxy-D-manno-octulosonic acid transferase

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(KDO)2-lipid IVA (2-8) 3-deoxy-D-manno-octulosonic acid transferase
EC number
IntEnz IntEnz view
ExPASy NiceZyme view
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

(KDO)2-lipid IVA (2-8) 3-deoxy-D-manno-octulosonic acid transferase (EC, KDO transferase, waaA (gene), kdtA (gene), 3-deoxy-D-manno-oct-2-ulosonic acid transferase, 3-deoxy-manno-octulosonic acid transferase) is an enzyme with systematic name CMP-3-deoxy-D-manno-oct-2-ulosonate:(KDO)2-lipid IVA 3-deoxy-D-manno-oct-2-ulosonate transferase ((2->8) glycosidic bond-forming).[1][2][3] This enzyme catalyses the following chemical reaction

alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + CMP-alpha-Kdo alpha-Kdo-(2->8)-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + CMP

The enzymes from Chlamydia transfer three or more 3-deoxy-D-manno-oct-2-ulosonate residues and generate genus-specific epitopes.


  1. ^ Lobau, S.; Mamat, U.; Brabetz, W.; Brade, H. (1995). "Molecular cloning, sequence analysis, and functional characterization of the lipopolysaccharide biosynthetic gene kdtA encoding 3-deoxy-α-D-manno-octulosonic acid transferase of Chlamydia pneumoniae strain TW-183". Mol. Microbiol. 18 (3): 391–399. doi:10.1111/j.1365-2958.1995.mmi_18030391.x. PMID 8748024. 
  2. ^ Mamat, U.; Baumann, M.; Schmidt, G.; Brade, H. (1993). "The genus-specific lipopolysaccharide epitope of Chlamydia is assembled in C. psittaci and C. trachomatis by glycosyltransferases of low homology". Mol. Microbiol. 10 (5): 935–941. doi:10.1111/j.1365-2958.1993.tb00965.x. PMID 7523826. 
  3. ^ Belunis, C.J.; Mdluli, K.E.; Raetz, C.R.; Nano, F.E. (1992). "A novel 3-deoxy-D-manno-octulosonic acid transferase from Chlamydia trachomatis required for expression of the genus-specific epitope". J. Biol. Chem. 267 (26): 18702–18707. PMID 1382060. 

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