(KDO)3-lipid IVA (2-4) 3-deoxy-D-manno-octulosonic acid transferase

From Wikipedia, the free encyclopedia
Jump to: navigation, search
(KDO)3-lipid IVA (2-4) 3-deoxy-D-manno-octulosonic acid transferase
Identifiers
EC number 2.4.99.15
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

(KDO)3-lipid IVA (2-4) 3-deoxy-D-manno-octulosonic acid transferase (EC 2.4.99.15, KDO transferase, waaA (gene), kdtA (gene), 3-deoxy-D-manno-oct-2-ulosonic acid transferase, 3-deoxy-manno-octulosonic acid transferase) is an enzyme with systematic name CMP-3-deoxy-D-manno-oct-2-ulosonate:(KDO)3-lipid IVA 3-deoxy-D-manno-oct-2-ulosonate transferase ((2->4) glycosidic bond-forming).[1][2] This enzyme catalyses the following chemical reaction

alpha-Kdo-(2->8)-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + CMP-alpha-Kdo alpha-Kdo-(2->8)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + CMP

The enzyme from Chlamydia psittaci transfers four KDO residues to lipid A, forming a branched tetrasaccharide.

References[edit]

  1. ^ Brabetz, W.; Lindner, B.; Brade, H. (2000). "Comparative analyses of secondary gene products of 3-deoxy-D-manno-oct-2-ulosonic acid transferases from Chlamydiaceae in Escherichia coli K-12". Eur. J. Biochem. 267 (17): 5458–5465. doi:10.1046/j.1432-1327.2000.01619.x. PMID 10951204. 
  2. ^ Holst, O.; Bock, K.; Brade, L.; Brade, H. (1995). "The structures of oligosaccharide bisphosphates isolated from the lipopolysaccharide of a recombinant Escherichia coli strain expressing the gene gseA [3-deoxy-D-manno-octulopyranosonic acid (Kdo) transferase] of Chlamydia psittaci 6BC". Eur. J. Biochem. 229 (1): 194–200. doi:10.1111/j.1432-1033.1995.tb20455.x. PMID 7744029. 

External links[edit]