(KDO)3-lipid IVA (2-4) 3-deoxy-D-manno-octulosonic acid transferase

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(KDO)3-lipid IVA (2-4) 3-deoxy-D-manno-octulosonic acid transferase
Identifiers
EC number 2.4.99.15
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

(KDO)3-lipid IVA (2-4) 3-deoxy-D-manno-octulosonic acid transferase (EC 2.4.99.15, KDO transferase, waaA (gene), kdtA (gene), 3-deoxy-D-manno-oct-2-ulosonic acid transferase, 3-deoxy-manno-octulosonic acid transferase) is an enzyme with systematic name CMP-3-deoxy-D-manno-oct-2-ulosonate:(KDO)3-lipid IVA 3-deoxy-D-manno-oct-2-ulosonate transferase ((2->4) glycosidic bond-forming).[1][2] This enzyme catalyses the following chemical reaction

alpha-Kdo-(2->8)-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + CMP-alpha-Kdo alpha-Kdo-(2->8)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + CMP

The enzyme from Chlamydia psittaci transfers four KDO residues to lipid A, forming a branched tetrasaccharide.

References[edit]

  1. ^ Brabetz W, Lindner B, Brade H (September 2000). "Comparative analyses of secondary gene products of 3-deoxy-D-manno-oct-2-ulosonic acid transferases from Chlamydiaceae in Escherichia coli K-12". European Journal of Biochemistry. 267 (17): 5458–65. doi:10.1046/j.1432-1327.2000.01619.x. PMID 10951204.
  2. ^ Holst O, Bock K, Brade L, Brade H (April 1995). "The structures of oligosaccharide bisphosphates isolated from the lipopolysaccharide of a recombinant Escherichia coli strain expressing the gene gseA [3-deoxy-D-manno-octulopyranosonic acid (Kdo) transferase] of Chlamydia psittaci 6BC". European Journal of Biochemistry. 229 (1): 194–200. doi:10.1111/j.1432-1033.1995.tb20455.x. PMID 7744029.

External links[edit]