(Methyl-Co(III) methanol-specific corrinoid protein):coenzyme M methyltransferase

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(Methyl-Co(III) methanol-specific corrinoid protein):coenzyme M methyltransferase
Identifiers
EC number 2.1.1.246
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

(Methyl-Co(III) methanol-specific corrinoid protein):coenzyme M methyltransferase (EC 2.1.1.246, methyltransferase 2, mtaA (gene)) is an enzyme with systematic name methylated methanol-specific corrinoid protein:coenzyme M methyltransferase.[1][2][3][4][5] This enzyme catalyses the following chemical reaction

[methyl-Co(III) methanol-specific corrinoid protein] + coenzyme M methyl-CoM + [Co(I) methanol-specific corrinoid protein]

Free methylcob(I)alamin can substitute for the corrinoid protein in vitro.

References[edit]

  1. ^ LeClerc, G.M.; Grahame, D.A. (1996). "Methylcobamide:coenzyme M methyltransferase isozymes from Methanosarcina barkeri. Physicochemical characterization, cloning, sequence analysis, and heterologous gene expression". J. Biol. Chem. 271: 18725–18731. doi:10.1074/jbc.271.31.18725. PMID 8702528. 
  2. ^ Harms, U.; Thauer, R.K. (1996). "Methylcobalamin: coenzyme M methyltransferase isoenzymes MtaA and MtbA from Methanosarcina barkeri. Cloning, sequencing and differential transcription of the encoding genes, and functional overexpression of the mtaA gene in Escherichia coli". Eur. J. Biochem. 235: 653–659. doi:10.1111/j.1432-1033.1996.00653.x. PMID 8654414. 
  3. ^ Sauer, K.; Thauer, R.K. (1997). "Methanol:coenzyme M methyltransferase from Methanosarcina barkeri. Zinc dependence and thermodynamics of the methanol:cob(I)alamin methyltransferase reaction". Eur. J. Biochem. 249: 280–285. doi:10.1111/j.1432-1033.1997.t01-1-00280.x. PMID 9363780. 
  4. ^ Sauer, K.; Harms, U.; Thauer, R.K. (1997). "Methanol:coenzyme M methyltransferase from Methanosarcina barkeri. Purification, properties and encoding genes of the corrinoid protein MT1". Eur. J. Biochem. 243: 670–677. doi:10.1111/j.1432-1033.1997.t01-1-00670.x. PMID 9057830. 
  5. ^ Sauer, K.; Thauer, R.K. (1999). "Methanol:coenzyme M methyltransferase from Methanosarcina barkeri – substitution of the corrinoid harbouring subunit MtaC by free cob(I)alamin". Eur. J. Biochem. 261: 674–681. doi:10.1046/j.1432-1327.1999.00355.x. PMID 10215883. 

External links[edit]