(Methyl-Co(III) methylamine-specific corrinoid protein):coenzyme M methyltransferase

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(Methyl-Co(III) methylamine-specific corrinoid protein):coenzyme M methyltransferase
Identifiers
EC number 2.1.1.247
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

(Methyl-Co(III) methylamine-specific corrinoid protein):coenzyme M methyltransferase (EC 2.1.1.247, methyltransferase 2, MT2, MT2-A, mtbA (gene)) is an enzyme with systematic name methylated monomethylamine-specific corrinoid protein:coenzyme M methyltransferase.[1][2][3][4][5] This enzyme catalyses the following chemical reaction

[methyl-Co(III) methylamine-specific corrinoid protein] + coenzyme M methyl-CoM + [Co(I) methylamine-specific corrinoid protein]

This enzyme contains zinc.

References[edit]

  1. ^ Burke, S.A.; Krzycki, J.A. (1995). "Involvement of the "A" isozyme of methyltransferase II and the 29-kilodalton corrinoid protein in methanogenesis from monomethylamine". J. Bacteriol. 177: 4410–4416. PMC 177191Freely accessible. PMID 7635826. 
  2. ^ LeClerc, G.M.; Grahame, D.A. (1996). "Methylcobamide:coenzyme M methyltransferase isozymes from Methanosarcina barkeri. Physicochemical characterization, cloning, sequence analysis, and heterologous gene expression". J. Biol. Chem. 271: 18725–18731. doi:10.1074/jbc.271.31.18725. PMID 8702528. 
  3. ^ Ferguson, D.J. Jr.; Krzycki, J.A. (1997). "Reconstitution of trimethylamine-dependent coenzyme M methylation with the trimethylamine corrinoid protein and the isozymes of methyltransferase II from Methanosarcina barkeri". J. Bacteriol. 179: 846–852. doi:10.1128/jb.179.3.846-852.1997. PMC 178769Freely accessible. PMID 9006042. 
  4. ^ Burke, S.A.; Lo, S.L.; Krzycki, J.A. (1998). "Clustered genes encoding the methyltransferases of methanogenesis from monomethylamine". J. Bacteriol. 180: 3432–3440. PMC 107300Freely accessible. PMID 9642198. 
  5. ^ Ferguson, D.J. Jr.; Gorlatova, N.; Grahame, D.A.; Krzycki, J.A. (2000). "Reconstitution of dimethylamine:coenzyme M methyl transfer with a discrete corrinoid protein and two methyltransferases purified from Methanosarcina barkeri". J. Biol. Chem. 275: 29053–29060. doi:10.1074/jbc.m910218199. PMID 10852929. 

External links[edit]