(Phosphatase 2A protein)-leucine-carboxy methyltransferase

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(phosphatase 2A protein)-leucine-carboxy methyltransferase
Identifiers
EC number 2.1.1.233
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

(phosphatase 2A protein)-leucine-carboxy methyltransferase (EC 2.1.1.233, leucine carboxy methyltransferase-1, LCMT1) is an enzyme with systematic name S-adenosyl-L-methionine:(phosphatase 2A protein)-leucine O-methyltransferase.[1][2] This enzyme catalyses the following chemical reaction

S-adenosyl-L-methionine + [phosphatase 2A protein]-leucine S-adenosyl-L-homocysteine + [phosphatase 2A protein]-leucine methyl ester

Methylates the C-terminal leucine of phosphatase 2A.

References[edit]

  1. ^ De Baere, I.; Derua, R.; Janssens, V.; Van Hoof, C.; Waelkens, E.; Merlevede, W.; Goris, J. (1999). "Purification of porcine brain protein phosphatase 2A leucine carboxyl methyltransferase and cloning of the human homologue". Biochemistry. 38: 16539–16547. doi:10.1021/bi991646a. PMID 10600115. 
  2. ^ Tsai, M.L.; Cronin, N.; Djordjevic, S. (2011). "The structure of human leucine carboxyl methyltransferase 1 that regulates protein phosphatase PP2A". Acta Crystallogr. D. 67: 14–24. doi:10.1107/s0907444910042204. PMID 21206058. 

External links[edit]