(R)-2-hydroxy-fatty-acid dehydrogenase

From Wikipedia, the free encyclopedia
Jump to navigation Jump to search
(R)-2-hydroxy-fatty-acid dehydrogenase
Identifiers
EC number1.1.1.98
CAS number37250-32-1
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO

In enzymology, a (R)-2-hydroxy-fatty-acid dehydrogenase (EC 1.1.1.98) is an enzyme that catalyzes the chemical reaction

(R)-2-hydroxystearate + NAD+ 2-oxostearate + NADH + H+

Thus, the two substrates of this enzyme are (R)-2-hydroxystearate and NAD+, whereas its 3 products are 2-oxostearate, NADH, and H+. This reaction is important in fatty acid metabolism.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is (R)-2-hydroxystearate:NAD+ oxidoreductase. Other names in common use include D-2-hydroxy fatty acid dehydrogenase, and 2-hydroxy fatty acid oxidase.

References[edit]

  • Levis GM (1970). "2-Hydroxy fatty acid oxidases of rat kidney". Biochem. Biophys. Res. Commun. 38 (3): 470&ndash, 7. doi:10.1016/0006-291X(70)90737-0. PMID 5443694.