Methanogen homoaconitase

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Methanogen homoaconitase
Identifiers
EC number 4.2.1.114
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

Methanogen homoaconitase (EC 4.2.1.114, methanogen HACN) is an enzyme with systematic name (R)-2-hydroxybutane-1,2,4-tricarboxylate hydro-lyase ((1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate-forming).[1] This enzyme catalyses the following chemical reaction

(R)-2-hydroxybutane-1,2,4-tricarboxylate (1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate (overall reaction)
(1a) (R)-2-hydroxybutane-1,2,4-tricarboxylate (Z)-but-1-ene-1,2,4-tricarboxylate + H2O
(1b) (Z)-but-1-ene-1,2,4-tricarboxylate + H2O (1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate

This enzyme catalyses several reactions in the pathway of coenzyme-B biosynthesis in methanogenic archaea.

References[edit]

  1. ^ Drevland, R.M.; Jia, Y.; Palmer, D.R.; Graham, D.E. (2008). "Methanogen homoaconitase catalyzes both hydrolyase reactions in coenzyme B biosynthesis". J. Biol. Chem. 283: 28888–28896. doi:10.1074/jbc.m802159200. PMC 2662002Freely accessible. PMID 18765671. 

External links[edit]