2-phosphosulfolactate phosphatase

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2-phosphosulfolactate phosphatase
Identifiers
EC number 3.1.3.71
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / QuickGO

In enzymology, a 2-phosphosulfolactate phosphatase (EC 3.1.3.71) is an enzyme that catalyzes the chemical reaction

(2R)-2-phospho-3-sulfolactate + H2O (2R)-3-sulfolactate + phosphate

Thus, the two substrates of this enzyme are (2R)-2-phospho-3-sulfolactate and H2O, whereas its two products are (2R)-3-sulfolactate and phosphate.

This enzyme belongs to the family of hydrolases, specifically those acting on phosphoric monoester bonds. The systematic name of this enzyme class is (R)-2-phospho-3-sulfolactate phosphohydrolase. Other names in common use include (2R)-phosphosulfolactate phosphohydrolase, and ComB phosphatase.

Structural studies[edit]

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 1VR0.

References[edit]

  • Graham DE, Graupner M, Xu H, White RH (2001). "Identification of coenzyme M biosynthetic 2-phosphosulfolactate phosphatase. A member of a new class of Mg(2+)-dependent acid phosphatases". Eur. J. Biochem. 268 (19): 5176–88. doi:10.1046/j.0014-2956.2001.02451.x. PMID 11589710.