4-phosphopantoate—beta-alanine ligase

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4-phosphopantoate—beta-alanine ligase
Identifiers
EC number 6.3.2.36
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

4-phosphopantoate—beta-alanine ligase (EC 6.3.2.36, phosphopantothenate synthetase, TK1686 protein) is an enzyme with systematic name (R)-4-phosphopantoate:beta-alanine ligase (AMP-forming).[1] This enzyme catalyses the following chemical reaction

ATP + (R)-4-phosphopantoate + beta-alanine AMP + diphosphate + (R)-4'-phosphopantothenate

The conversion of (R)-pantoate to (R)-4'-phosphopantothenate is part of the pathway leading to biosynthesis of 4'-phosphopantetheine.

References[edit]

  1. ^ Yokooji, Y.; Tomita, H.; Atomi, H.; Imanaka, T. (2009). "Pantoate kinase and phosphopantothenate synthetase, two novel enzymes necessary for CoA biosynthesis in the Archaea". J. Biol. Chem. 284: 28137–28145. doi:10.1074/jbc.m109.009696. PMC 2788864Freely accessible. PMID 19666462. 

External links[edit]