Diacetyl reductase ((R)-acetoin forming)

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Diacetyl reductase, (R)-acetoin forming
Identifiers
EC number 1.1.1.303
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

Diacetyl reductase ((R)-acetoin forming) (EC 1.1.1.303, (R)-acetoin dehydrogenase) is an enzyme with systematic name (R)-acetoin:NAD+ oxidoreductase.[1][2] This enzyme catalyses the following chemical reaction

(R)-acetoin + NAD+ diacetyl + NADH + H+

The reaction is catalysed in the reverse direction, this activity is usually associated with butanediol dehydrogenase activity (EC 1.1.1.4 or EC 1.1.1.76). While the butanediol dehydrogenase activity is reversible, diacetyl reductase activity is irreversible, this enzyme has been reported in the yeast Saccharomyces cerevisiae. This enzyme is different from EC 1.1.1.304, diacetyl reductase ((S)-acetoin forming).

References[edit]

  1. ^ Heidlas, J.; Tressl, R. (1990). "Purification and characterization of a (R)-2,3-butanediol dehydrogenase from Saccharomyces cerevisiae". Arch. Microbiol. 154 (3): 267–273. doi:10.1007/bf00248966. PMID 2222122. 
  2. ^ Gonzalez, E.; Fernandez, M.R.; Larroy, C.; Sola, L.; Pericas, M.A.; Pares, X.; Biosca, J.A. (2000). "Characterization of a (2R,3R)-2,3-butanediol dehydrogenase as the Saccharomyces cerevisiae YAL060W gene product. Disruption and induction of the gene". J. Biol. Chem. 275: 35876–35885. doi:10.1074/jbc.M003035200. PMID 10938079.