(R)-citramalate synthase

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(R)-citramalate synthase
Identifiers
EC number 2.3.1.182
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

(R)-citramalate synthase (EC 2.3.1.182, CimA) is an enzyme.[1][2] This enzyme catalyses the following chemical reaction

acetyl-CoA + pyruvate + H2O CoA + (2R)-2-hydroxy-2-methylbutanedioate

This enzyme participates in a novel pyruvate pathway for isoleucine biosynthesis.

References[edit]

  1. ^ Howell, D.M.; Xu, H.; White, R.H. (1999). "(R)-Citramalate synthase in methanogenic archaea". J. Bacteriol. 181 (1): 331–333. PMC 103565Freely accessible. PMID 9864346. 
  2. ^ Xu, H.; Zhang, Y.; Guo, X.; Ren, S.; Staempfli, A.A.; Chiao, J.; Jiang, W.; Zhao, G. (2004). "Isoleucine biosynthesis in Leptospira interrogans serotype 1ai strain 56601 proceeds via a threonine-independent pathway". J. Bacteriol. 186 (16): 5400–5409. doi:10.1128/jb.186.16.5400-5409.2004. PMC 490871Freely accessible. PMID 15292141. 

External links[edit]