Lactoyl-CoA dehydratase

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lactoyl-CoA dehydratase
Identifiers
EC number 4.2.1.54
CAS number 9031-12-3
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / QuickGO

In enzymology, a lactoyl-CoA dehydratase (EC 4.2.1.54) is an enzyme that catalyzes the chemical reaction

lactoyl-CoA acryloyl-CoA + H2O

Hence, this enzyme has one substrate, lactoyl-CoA, and two products, acryloyl-CoA and H2O.

This enzyme belongs to the family of lyases, specifically the hydro-lyases, which cleave carbon-oxygen bonds, the systematic name of this enzyme class is lactoyl-CoA hydro-lyase (acryloyl-CoA-forming). Other names in common use include lactoyl coenzyme A dehydratase, lactyl-coenzyme A dehydrase, lactyl CoA dehydratase, acrylyl coenzyme A hydratase, and lactoyl-CoA hydro-lyase. This enzyme participates in propanoate metabolism and styrene degradation.

References[edit]

  • BALDWIN RL, WOOD WA, EMERY RS (1965). "LACTATE METABOLISM BY PEPTOSTREPTOCOCCUS ELSDENII: EVIDENCE FOR LACTYL COENZYME A DEHYDRASE". Biochim. Biophys. Acta. 97: 202–13. doi:10.1016/0304-4165(65)90084-x. PMID 14292829.