Hydroxymethylglutaryl-CoA reductase

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Hydroxymethylglutaryl-CoA reductase
Identifiers
EC number 1.1.1.88
CAS number 37250-24-1
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

In enzymology, a Hydroxymethylglutaryl-CoA reductase (EC 1.1.1.88) is an enzyme that catalyzes the chemical reaction

(R)-mevalonate + CoA + 2 NAD+ 3-hydroxy-3-methylglutaryl-CoA + 2 NADH + 2 H+

The 3 substrates of this enzyme are (R)-mevalonate, CoA, and NAD+, whereas its 3 products are 3-hydroxy-3-methylglutaryl-CoA, NADH, and H+.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is (R)-mevalonate:NAD+ oxidoreductase (CoA-acylating).[1] Other names in common use include beta-hydroxy-beta-methylglutaryl coenzyme A reductase, beta-hydroxy-beta-methylglutaryl CoA-reductase, 3-hydroxy-3-methylglutaryl coenzyme A reductase, and hydroxymethylglutaryl coenzyme A reductase.

References[edit]

  1. ^ Fimognari, G.M.; Rodwell, V.W. (1965). "Substrate-competitive inhibition of bacterial mevalonate:nicotinamide-adenine dinucleotide oxidoreductase (acylating CoA)". Biochemistry. 4: 2086–2090. doi:10.1021/bi00886a025. 

External links[edit]