(RS)-1-benzyl-1,2,3,4-tetrahydroisoquinoline N-methyltransferase

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(RS)-1-benzyl-1,2,3,4-tetrahydroisoquinoline N-methyltransferase
Identifiers
EC number 2.1.1.115
CAS number 132084-82-3
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / QuickGO

In enzymology, a (RS)-1-benzyl-1,2,3,4-tetrahydroisoquinoline N-methyltransferase is an enzyme that catalyzes the chemical reaction:[1]

EC 2.1.1.115 rxn.png
S-adenosyl-L-methionine + (RS)-1-benzyl-1,2,3,4-tetrahydroisoquinoline S-adenosyl-L-homocysteine + N-methyl-(RS)-1-benzyl-1,2,3,4-tetrahydroisoquinoline

This enzyme participates in alkaloid biosynthesis.

Nomenclature[edit]

This enzyme belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases. The systematic name of this enzyme class is S-adenosyl-L-methionine:(RS)-1-benzyl-1,2,3,4-tetrahydroisoquinoline N-methyltransferase. This enzyme is also called norreticuline N-methyltransferase.

References[edit]

  1. ^ Frenzel T, Zenk MH (1990). "Purification and characterization of three isoforms of S-adenosyl-L-methionine: (R,S)-tetrahydrobenzyl-isoquinoline N-methyltransferase from Berberis koetineana cell cultures". Phytochemistry. 29 (11): 3491–3497. doi:10.1016/0031-9422(90)85263-F.