2-haloacid dehalogenase (configuration-retaining)

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2-haloacid dehalogenase (configuration-retaining)
Identifiers
EC number 3.8.1.11
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

2-haloacid dehalogenase (configuration-retaining) (EC 3.8.1.11, 2-haloalkanoic acid dehalogenase, 2-haloalkanoid acid halidohydrolase, DL-2-haloacid dehalogenase, DL-DEXr) is an enzyme with systematic name (S)-2-haloacid dehalogenase (configuration-retaining).[1][2] This enzyme catalyses the following chemical reaction

(1) (S)-2-haloacid + H2O (S)-2-hydroxyacid + halide
(2) (R)-2-haloacid + H2O (R)-2-hydroxyacid + halide

Dehalogenates both (S)- and (R)-2-haloalkanoic acids to the corresponding (S)- and (R)-hydroxyalkanoic acids.

References[edit]

  1. ^ Weightman, A.J.; Weightman, A.L.; Slater, J.H. (1982). "Stereospecificity of 2-monochloropropionate dehalogenation by the two dehalogenases of Pseudomonas P3: evidence for two different dehalogenation mechanisms". J. Gen. Microbiol. 128 (8): 1755–1762. doi:10.1099/00221287-128-8-1755. PMID 7142958. 
  2. ^ Soda, K.; Kurihara, T.; Liu, J.-Q.; Nardi-Dei, V.; Park, C.; Miyagi, M.; Tsunasawa, S.; Esaki, N. (1996). "Bacterial 2-haloacid dehalogenases: Structures and catalytic properties". Pure Appl. Chem. 68: 2097–2103. doi:10.1351/pac199668112097. 

External links[edit]