(S)-2-methylmalate dehydratase

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(S)-2-methylmalate dehydratase
Identifiers
EC number 4.2.1.34
CAS number 9027-94-5
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / QuickGO

In enzymology, a (S)-2-methylmalate dehydratase (EC 4.2.1.34) is an enzyme that catalyzes the chemical reaction

(S)-2-methylmalate 2-methylfumarate + H2O

Hence, this enzyme has one substrate, (S)-2-methylmalate, and two products, 2-methylfumarate and H2O.

This enzyme belongs to the family of lyases, specifically the hydro-lyases, which cleave carbon-oxygen bonds, the systematic name of this enzyme class is (S)-2-methylmalate hydro-lyase (2-methylfumarate-forming). Other names in common use include mesaconate hydratase, (+)-citramalate hydro-lyase, L-citramalate hydrolase, citramalate dehydratase, (+)-citramalic hydro-lyase, mesaconate mesaconase, mesaconase, and (S)-2-methylmalate hydro-lyase. This enzyme participates in c5-branched dibasic acid metabolism. In addition, the family of lyases which is also an enzyme catalyzes the breaking the elimination reaction of the variety of amounts of chemical bonds from hydrolysis (a substitution reaction ) and oxidation, which forms a new double bond or a new ring structure.[1]

References[edit]

  1. ^ "Blair AH, Barker HA (1966). , Wang CC, Barker HA (1969). There are also other enzymes in international Union of Biochemistry and Molecular Biology.
  • Blair AH, Barker HA (1966). "Assay and purification of (+)-citramalate hydro-lyase components from Clostridium tetanomorphum". J. Biol. Chem. 241 (2): 400–8. PMID 5903732. 
  • Wang CC, Barker HA (1969). "Purification and properties of L-citramalate hydrolyase". J. Biol. Chem. 244 (10): 2516–26. PMID 5769987.