Hydroxyacid-oxoacid transhydrogenase

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hydroxyacid-oxoacid transhydrogenase
Identifiers
EC number 1.1.99.24
CAS number 117698-31-4
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / QuickGO

In enzymology, a hydroxyacid-oxoacid transhydrogenase (EC 1.1.99.24) is an enzyme that catalyzes the chemical reaction

(S)-3-hydroxybutanoate + 2-oxoglutarate acetoacetate + (R)-2-hydroxyglutarate

Thus, the two substrates of this enzyme are (S)-3-hydroxybutanoate and 2-oxoglutarate, whereas its two products are acetoacetate and (R)-2-hydroxyglutarate.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with other acceptors, the systematic name of this enzyme class is (S)-3-hydroxybutanoate:2-oxoglutarate oxidoreductase. This enzyme is also called transhydrogenase, hydroxy acid-oxo acid.[1]

See also[edit]

References[edit]

  1. ^ Kaufman EE, Nelson T, Fales HM, Levin DM (1988). "Isolation and characterization of a hydroxyacid-oxoacid transhydrogenase from rat kidney mitochondria". J. Biol. Chem. 263 (32): 16872–9. PMID 3182820.