Glutamate-1-semialdehyde 2,1-aminomutase

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glutamate-1-semialdehyde 2,1-aminomutase
2epj.jpg
2epj, Aeropyrum pernix (Archaea)
Identifiers
EC number 5.4.3.8
CAS number 68518-07-0
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / QuickGO

In enzymology, a glutamate-1-semialdehyde 2,1-aminomutase (EC 5.4.3.8) is an enzyme that catalyzes the chemical reaction

L-glutamate 1-semialdehyde 5-aminolevulinate

Hence, this enzyme has one substrate, L-glutamate-1-semialdehyde, and one product, 5-aminolevulinate.

This enzyme belongs to the family of isomerases, specifically those intramolecular transferases transferring amino groups, the systematic name of this enzyme class is (S)-4-amino-5-oxopentanoate 4,5-aminomutase. This enzyme is also called glutamate-1-semialdehyde aminotransferase. This enzyme participates in porphyrin and chlorophyll biosynthesis, it employs one cofactor, pyridoxal phosphate.

Structural studies[edit]

As of late 2007, 10 structures have been solved for this class of enzymes, with PDB accession codes 2CFB, 2E7U, 2EPJ, 2GSA, 2HOY, 2HOZ, 2HP1, 2HP2, 3GSB, and 4GSA.

References[edit]

  • Gough SP; Kannangara CG (1978). "Biosynthesis of delta-aminolevulinate in greening barley leaves: glutamate 1-semialdehyde aminotransferase". Carlsberg Res. Commun. 43 (3): 185–194. doi:10.1007/BF02914241.