(S)-cheilanthifoline synthase

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(S)-cheilanthifoline synthase
EC number1.14.21.2
CAS number138791-27-2
IntEnzIntEnz view
ExPASyNiceZyme view
MetaCycmetabolic pathway
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO

In enzymology, a (S)-cheilanthifoline synthase (EC is an enzyme that catalyzes the chemical reaction

(S)-scoulerine + NADPH + H+ + O2 (S)-cheilanthifoline + NADP+ + 2 H2O

The 4 substrates of this enzyme are (S)-scoulerine, NADPH, H+, and O2, whereas its 3 products are (S)-cheilanthifoline, NADP+, and H2O.

This enzyme belongs to the family of oxidoreductases, specifically those acting on paired donors, with O2 as oxidant and incorporation or reduction of oxygen, the oxygen incorporated need not be derived from O2 with NADH or NADPH as one donor, and the other dehydrogenated. The systematic name of this enzyme class is (S)-scoulerine,NADPH:oxygen oxidoreductase (methylenedioxy-bridge-forming). This enzyme is also called (S)-scoulerine oxidase (methylenedioxy-bridge-forming). This enzyme participates in alkaloid biosynthesis i.


  • Bauer W; Zenk MH (1991). "Two methylenedioxy bridge-forming cytochrome P-450 dependent enzymes are involved in (S)-stylopine biosynthesis". Phytochemistry. 30 (9): 2953&ndash, 2961. doi:10.1016/S0031-9422(00)98230-X.