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carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase
Dihydroorotase (fragment) dimer, Human
Symbol CAD
Entrez 790
HUGO 1424
OMIM 114010
RefSeq NM_004341
UniProt P27708
Other data
EC number
Locus Chr. 2 p22-p21

Dihydroorotase (EC, carbamoylaspartic dehydrase, dihydroorotate hydrolase) is an enzyme which converts carbamoyl aspartic acid into 4,5-dihydroorotic acid in the biosynthesis of pyrimidines.[1][2] It forms a multifunctional enzyme with carbamoyl phosphate synthetase and aspartate transcarboymalase.

See also[edit]


  1. ^ Cooper, C.; Wilson, D.W. (1954). "Biosynthesis of pyrimidines". Fed. Proc. 13: 194–194. 
  2. ^ Lieberman, I.; Kornberg, A. (1954). "Enzymatic synthesis and breakdown of a pyrimidine, orotic acid. II. Dihydroorotic acid, ureidosuccinic acid, and 5-carboxymethylhydantoin" (PDF). J. Biol. Chem. 207: 911–924. PMID 13163076. 

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