Ethylmalonyl-CoA decarboxylase

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ECHDC1
Identifiers
Aliases ECHDC1, HEL-S-76, MMCD, dJ351K20.2, ethylmalonyl-CoA decarboxylase 1
External IDs MGI: 1277169 HomoloGene: 23106 GeneCards: ECHDC1
EC number 4.1.1.41
Gene location (Human)
Chromosome 6 (human)
Chr. Chromosome 6 (human)[1]
Chromosome 6 (human)
Genomic location for ECHDC1
Genomic location for ECHDC1
Band 6q22.33 Start 127,288,710 bp[1]
End 127,343,609 bp[1]
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001002030
NM_001105544
NM_001105545
NM_001139510
NM_018479

NM_001110195
NM_025855

RefSeq (protein)

NP_001002030
NP_001099014
NP_001099015
NP_001132982
NP_060949

NP_001103665
NP_080131

Location (UCSC) Chr 6: 127.29 – 127.34 Mb Chr 6: 29.31 – 29.35 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse
Ethylmalonyl-CoA decarboxylase
Identifiers
EC number 4.1.1.94
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

Ethylmalonyl-CoA decarboxylase (EC 4.1.1.94) is an enzyme with systematic name (S)-ethylmalonyl-CoA carboxy-lyase (butanoyl-CoA-forming).[5] This enzyme catalyses the following chemical reaction

(S)-ethylmalonyl-CoA butanoyl-CoA + CO2

The vertebrate enzyme decarboxylates ethylmalonyl-CoA.

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000093144 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000019883 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ Linster CL, Noël G, Stroobant V, Vertommen D, Vincent MF, Bommer GT, Veiga-da-Cunha M, Van Schaftingen E (Dec 2011). "Ethylmalonyl-CoA decarboxylase, a new enzyme involved in metabolite proofreading". The Journal of Biological Chemistry. 286 (50): 42992–3003. doi:10.1074/jbc.m111.281527. PMC 3234807Freely accessible. PMID 22016388. 

External links[edit]