Lactate—malate transhydrogenase

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lactate—malate transhydrogenase
Identifiers
EC number 1.1.99.7
CAS number 9077-15-0
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / QuickGO

In enzymology, a lactate—malate transhydrogenase (EC 1.1.99.7) is an enzyme that catalyzes the chemical reaction

(S)-lactate + oxaloacetate pyruvate + malate

Thus, the two substrates of this enzyme are (S)-lactate and oxaloacetate, whereas its two products are pyruvate and malate.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with other acceptors, the systematic name of this enzyme class is (S)-lactate:oxaloacetate oxidoreductase. This enzyme is also called malate-lactate transhydrogenase. This enzyme participates in pyruvate metabolism, it employs one cofactor, nicotinamide D-ribonucleotide.

References[edit]

Further reading[edit]

  • Allen SH (1966). "The isolation and characterization of malate-lactate transhydrogenase from Micrococcus lactilyticus". J. Biol. Chem. 241 (22): 5266–75. PMID 4289051. 
  • Allen SH, Patil JR (1972). "Studies on the structure and mechanism of action of the malate-lactate transhydrogenase". J. Biol. Chem. 247 (3): 909–16. PMID 4333516.