Malate dehydrogenase (NAD(P)+)

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Malate dehydrogenase (NAD(P)+)
Identifiers
EC number 1.1.1.299
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

Malate dehydrogenase (NAD(P)+) (EC 1.1.1.299, MdH II, NAD(P)+-dependent malate dehyrogenase) is an enzyme with systematic name (S)-malate:NAD(P)+ oxidoreductase.[1] This enzyme catalyses the following chemical reaction

(S)-malate + NAD(P)+ oxaloacetate + NAD(P)H + H+

This enzyme, which was characterized from the methanogenic archaeon Methanobacterium thermoautotrophicum, catalyses only the reduction of oxaloacetate, and can use NAD+ and NADP+ with similar specific activity. It is different from EC 1.1.1.37 (malate dehydrogenase (NAD+)), EC 1.1.1.82 (malate dehydrogenase (NADP+)) and EC 1.1.5.4 (malate dehydrogenase (quinone)).

References[edit]

  1. ^ Thompson, H.; Tersteegen, A.; Thauer, R. K.; Hedderich, R. (1998). "Two malate dehydrogenases in Methanobacterium thermoautotrophicum". Arch. Microbiol. 170: 38–42. doi:10.1007/s002030050612. PMID 9639601. 

External links[edit]