(S)-mandelate dehydrogenase

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(S)-mandelate dehydrogenase
Identifiers
EC number 1.1.99.31
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

In enzymology, a (S)-mandelate dehydrogenase (EC 1.1.99.31) is an enzyme that catalyzes the chemical reaction

(S)-2-hydroxy-2-phenylacetate + acceptor 2-oxo-2-phenylacetate + reduced acceptor

Thus, the two substrates of this enzyme are (S)-2-hydroxy-2-phenylacetate and acceptor, whereas its two products are 2-oxo-2-phenylacetate and reduced acceptor.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with other acceptors, the systematic name of this enzyme class is (S)-2-hydroxy-2-phenylacetate:acceptor 2-oxidoreductase. This enzyme is also called MDH.

References[edit]

  • Lehoux IE, Mitra B (1999). "(S)-Mandelate dehydrogenase from Pseudomonas putida: mechanistic studies with alternate substrates and pH and kinetic isotope effects". Biochemistry. 38 (18): 5836–48. doi:10.1021/bi990024m. PMID 10231535. 
  • Dewanti AR, Xu Y, Mitra B (2004). "Role of glycine 81 in (S)-mandelate dehydrogenase from Pseudomonas putida in substrate specificity and oxidase activity". Biochemistry. 43 (33): 10692–700. doi:10.1021/bi049005p. PMID 15311930. 
  • Dewanti AR, Xu Y, Mitra B (2004). "Esters of mandelic acid as substrates for (S)-mandelate dehydrogenase from Pseudomonas putida: implications for the reaction mechanism". Biochemistry. 43 (7): 1883–90. doi:10.1021/bi036021y. PMID 14967029.