Peroxyureidoacrylate/ureidoacrylate amidohydrolase

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Peroxyureidoacrylate/ureidoacrylate amidohydrolase
Identifiers
EC number 3.5.1.110
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

Peroxyureidoacrylate/ureidoacrylate amidohydrolase (EC 3.5.1.110, RutB) is an enzyme with systematic name (Z)-3-ureidoacrylate peracid amidohydrolase.[1] This enzyme catalyses the following chemical reaction sequences:

  • (Z)-3-ureidoacrylate peracid + H2O ⇌ (Z)-3-peroxyaminoacrylate + CO2 + NH3 (overall reaction)
    1. (Z)-3-ureidoacrylate peracid + H2O ⇌ (Z)-3-peroxyaminoacrylate + carbamate
    2. carbamate ⇌ CO2 + NH3 (spontaneous)
  • (Z)-2-methylureidoacrylate peracid + H2O ⇌ (Z)-2-methylperoxyaminoacrylate + CO2 + NH3 (overall reaction)
    1. (Z)-2-methylureidoacrylate peracid + H2O ⇌ (Z)-2-methylperoxyaminoacrylate + carbamate
    2. carbamate ⇌ CO2 + NH3 (spontaneous)

The enzyme also shows activity towards ureidoacrylate.

References[edit]

  1. ^ Kim, K.S.; Pelton, J.G.; Inwood, W.B.; Andersen, U.; Kustu, S.; Wemmer, D.E. (2010). "The Rut pathway for pyrimidine degradation: novel chemistry and toxicity problems". J. Bacteriol. 192: 4089–4102. doi:10.1128/JB.00201-10. PMC 2916427Freely accessible. PMID 20400551. 

External links[edit]