Phenylacetaldoxime dehydratase

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Phenylacetaldoxime dehydratase
Identifiers
EC number 4.99.1.7
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

In enzymology, a phenylacetaldoxime dehydratase (EC 4.99.1.7) is an enzyme that catalyzes the chemical reaction

(Z)-phenylacetaldehyde oxime phenylacetonitrile + H2O

Hence, this enzyme has one substrate, (Z)-phenylacetaldehyde oxime, and two products, phenylacetonitrile and H2O.

This enzyme belongs to the family of lyases, specifically the "catch-all" class of lyases that do not fit into any other sub-class, the systematic name of this enzyme class is (Z)-phenylacetaldehyde-oxime hydro-lyase (phenylacetonitrile-forming). Other names in common use include PAOx dehydratase, arylacetaldoxime dehydratase, OxdB, and (Z)-phenylacetaldehyde-oxime hydro-lyase. This enzyme participates in styrene degradation.

References[edit]

  • Kato Y, Nakamura K, Sakiyama H, Mayhew SG, Asano Y (2000). "Novel heme-containing lyase, phenylacetaldoxime dehydratase from Bacillus sp. strain OxB-1: purification, characterization, and molecular cloning of the gene". Biochemistry. 39 (4): 800–9. doi:10.1021/bi991598u. PMID 10651646. 
  • Kobayashi K, Yoshioka S, Kato Y, Asano Y, Aono S (2005). "Regulation of aldoxime dehydratase activity by redox-dependent change in the coordination structure of the aldoxime-heme complex". J. Biol. Chem. 280 (7): 5486–90. doi:10.1074/jbc.M410474200. PMID 15596434.