Hexaprenyl diphosphate synthase (geranylgeranyl-diphosphate specific)

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Hexaprenyl diphosphate synthase (geranylgeranyl-diphosphate specific)
Identifiers
EC number 2.5.1.82
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

Hexaprenyl diphosphate synthase (geranylgeranyl-diphosphate specific) (EC 2.5.1.82, HexPS, (all-E) hexaprenyl diphosphate synthase, (all-trans) hexaprenyl diphosphate synthase, hexaprenyl pyrophosphate synthase, HexPPs, hexaprenyl diphosphate synthase) is an enzyme with systematic name geranylgeranyl-diphosphate:isopentenyl-diphosphate transferase (adding 2 isopentenyl units).[1][2][3] This enzyme catalyses the following chemical reaction

geranylgeranyl diphosphate + 2 isopentenyl diphosphate 2 diphosphate + all-trans-hexaprenyl diphosphate

The enzyme prefers geranylgeranyl diphosphate to farnesyl diphosphate as an allylic substrate.

References[edit]

  1. ^ Hemmi, H.; Ikejiri, S.; Yamashita, S.; Nishino, T. (2002). "Novel medium-chain prenyl diphosphate synthase from the thermoacidophilic archaeon Sulfolobus solfataricus". J. Bacteriol. 184 (3): 615–620. doi:10.1128/JB.184.3.615-620.2002. PMC 139513Freely accessible. PMID 11790729. 
  2. ^ Hemmi, H.; Noike, M.; Nakayama, T.; Nishino, T. (2002). "Change of product specificity of hexaprenyl diphosphate synthase from Sulfolobus solfataricus by introducing mimetic mutations". Biochem. Biophys. Res. Commun. 297 (5): 1096–1101. doi:10.1016/S0006-291X(02)02348-3. PMID 12372398. 
  3. ^ Sun, H.Y.; Ko, T.P.; Kuo, C.J.; Guo, R.T.; Chou, C.C.; Liang, P.H.; Wang, A.H. (2005). "Homodimeric hexaprenyl pyrophosphate synthase from the thermoacidophilic crenarchaeon Sulfolobus solfataricus displays asymmetric subunit structures". J. Bacteriol. 187 (23): 8137–8148. doi:10.1128/JB.187.23.8137-8148.2005. PMC 1291270Freely accessible. PMID 16291686. 

External links[edit]