(butirosin acyl-carrier protein)—L-glutamate ligase

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(butirosin acyl-carrier protein)—L-glutamate ligase
Identifiers
EC number 6.2.1.39
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

(butirosin acyl-carrier protein)—L-glutamate ligase (EC 6.2.1.39, [BtrI acyl-carrier protein]—L-glutamate ligase, BtrJ) is an enzyme with systematic name (BtrI acyl-carrier protein):L-glutamate ligase (ADP-forming).[1] This enzyme catalyses the following chemical reaction

(1) ATP + L-glutamate + BtrI acyl-carrier protein ADP + phosphate + L-glutamyl-[BtrI acyl-carrier protein]
(2) ATP + L-glutamate + 4-amino butanoyl-[BtrI acyl-carrier protein] ADP + phosphate + 4-(gamma-L-glutamylamino)butanoyl-[BtrI acyl-carrier protein]

This enzyme catalyses two steps in the biosynthesis of the side chain of the aminoglycoside antibiotics of the butirosin family.

References[edit]

  1. ^ Li, Y.; Llewellyn, N.M.; Giri, R.; Huang, F.; Spencer, J.B. (2005). "Biosynthesis of the unique amino acid side chain of butirosin: possible protective-group chemistry in an acyl carrier protein-mediated pathway". Chem. Biol. 12 (6): 665–675. doi:10.1016/j.chembiol.2005.04.010. PMID 15975512. 

External links[edit]