(carboxyethyl)arginine beta-lactam-synthase

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(carboxyethyl)arginine beta-lactam-synthase
1mc1.png
beta-lactam synthetase. PDB 1mc1 [1]
Identifiers
EC number 6.3.3.4
CAS number 68247-54-1
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / QuickGO

In enzymology, a (carboxyethyl)arginine beta-lactam-synthase (EC 6.3.3.4) is an enzyme that catalyzes the chemical reaction

ATP + L-N2-(2-carboxyethyl)arginine AMP + diphosphate + deoxyamidinoproclavaminate

Thus, the two substrates of this enzyme are ATP and L-N2-(2-carboxyethyl)arginine, whereas its 3 products are AMP, diphosphate, and deoxyamidinoproclavaminate.

This enzyme belongs to the family of ligases, specifically the cyclo-ligases, which form carbon-nitrogen bonds. The systematic name of this enzyme class is L-N2-(2-carboxyethyl)arginine cyclo-ligase (AMP-forming). This enzyme is also called L-2-N-(2-carboxyethyl)arginine cyclo-ligase (AMP-forming). This enzyme participates in clavulanic acid biosynthesis.

References[edit]

  1. ^ Miller, M. T.; Bachmann, B. O.; Townsend, C. A.; Rosenzweig, A. C. (2002). "The catalytic cycle of beta -lactam synthetase observed by x-ray crystallographic snapshots". Proceedings of the National Academy of Sciences. 99 (23): 14752–14757. doi:10.1073/pnas.232361199. PMC 137491Freely accessible. PMID 12409610. 

Further reading[edit]