(citrate (pro-3S)-lyase) ligase

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[citrate (pro-3S)-lyase] ligase
Identifiers
EC number 6.2.1.22
CAS number 52660-22-7
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / QuickGO

In enzymology, a citrate (pro-3S)-lyase ligase (EC 6.2.1.22) is an enzyme that catalyzes the chemical reaction

ATP + acetate + citrate (pro-3S)-lyase(thiol form) AMP + diphosphate + citrate (pro-3S)-lyase(acetyl form)

The 3 substrates of this enzyme are ATP, acetate, and citrate (pro-3S)-lyase(thiol form), whereas its 3 products are AMP, diphosphate, and citrate (pro-3S)-lyase(acetyl form).

This enzyme belongs to the family of ligases, specifically those forming carbon-sulfur bonds as acid-thiol ligases, the systematic name of this enzyme class is acetate:citrate (pro-3S)-lyase(thiol-form) ligase (AMP-forming). Other names in common use include citrate lyase ligase, citrate lyase synthetase, acetate: SH-acyl-carrier-protein enzyme ligase (AMP), acetate:HS-citrate lyase ligase, and acetate:citrate-(pro-3S)-lyase(thiol-form) ligase (AMP-forming). This enzyme participates in two-component system - general.

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