(d)CMP kinase

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(d)CMP kinase
Identifiers
EC number 2.7.4.25
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

(d)CMP kinase (EC 2.7.4.25, prokaryotic cytidylate kinase, deoxycytidylate kinase, dCMP kinase, deoxycytidine monophosphokinase) is an enzyme with systematic name ATP:(d)CMP phosphotransferase.[1][2] This enzyme catalyses the following chemical reaction

ATP + (d)CMP ADP + (d)CDP

The prokaryotic cytidine monophosphate kinase specifically phosphorylates CMP (or dCMP).

References[edit]

  1. ^ Bertrand, T.; Briozzo, P.; Assairi, L.; Ofiteru, A.; Bucurenci, N.; Munier-Lehmann, H.; Golinelli-Pimpaneau, B.; Barzu, O.; Gilles, A.M. (2002). "Sugar specificity of bacterial CMP kinases as revealed by crystal structures and mutagenesis of Escherichia coli enzyme". J. Mol. Biol. 315: 1099–1110. doi:10.1006/jmbi.2001.5286. PMID 11827479. 
  2. ^ Thum, C.; Schneider, C.Z.; Palma, M.S.; Santos, D.S.; Basso, L.A. (2009). "The Rv1712 Locus from Mycobacterium tuberculosis H37Rv codes for a functional CMP kinase that preferentially phosphorylates dCMP". J. Bacteriol. 191: 2884–2887. doi:10.1128/jb.01337-08. PMC 2668428Freely accessible. PMID 19181797. 

External links[edit]