Gamma-glutamylcyclotransferase

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gamma-glutamylcyclotransferase
Identifiers
EC number 2.3.2.4
CAS number 9045-44-7
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / QuickGO

In enzymology, a gamma-glutamylcyclotransferase (EC 2.3.2.4) is an enzyme that catalyzes the chemical reaction

(5-L-glutamyl)-L-amino acid 5-oxoproline + L-amino acid

Hence, this enzyme has one substrate, (5-L-glutamyl)-L-amino acid, and two products, 5-oxoproline and L-amino acid.

This enzyme belongs to the family of transferases, specifically the aminoacyltransferases, the systematic name of this enzyme class is (5-L-glutamyl)-L-amino-acid 5-glutamyltransferase (cyclizing). Other names in common use include gamma-glutamyl-amino acid cyclotransferase, gamma-L-glutamylcyclotransferase, and L-glutamic cyclase. This enzyme participates in glutathione metabolism.

Structural studies[edit]

As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes 2PN7 and 2RBH.

References[edit]

  • Bodnaryk RP; McGirr L (1973). "Purification, properties and function of a unique gamma-glutamyl cyclotransferase from the housefly, Musca domestica L". Biochim. Biophys. Acta. 315: 352–362. doi:10.1016/0005-2744(73)90264-7. 
  • Orlowski M, Richman PG, Meister A (1969). "Isolation and properties of gamma-L-glutamylcyclotransferase from human brain". Biochemistry. 8 (3): 1048–1055. doi:10.1021/bi00831a036. PMID 5781001.