(hydroxymethylglutaryl-CoA reductase (NADPH))-phosphatase

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[hydroxymethylglutaryl-CoA reductase (NADPH)]-phosphatase
Identifiers
EC number 3.1.3.47
CAS number 73507-97-8
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / QuickGO

In enzymology, a [hydroxymethylglutaryl-CoA reductase (NADPH)]-phosphatase (EC 3.1.3.47) is an enzyme that catalyzes the chemical reaction

[hydroxymethylglutaryl-CoA reductase (NADPH)] phosphate + H2O [hydroxymethylglutaryl-CoA reductase (NADPH)] + phosphate

Thus, the two substrates of this enzyme are hydroxymethylglutaryl-CoA reductase (NADPH) phosphate and H2O, whereas its two products are hydroxymethylglutaryl-CoA reductase (NADPH) and phosphate.

This enzyme belongs to the family of hydrolases, specifically those acting on phosphoric monoester bonds, the systematic name of this enzyme class is [hydroxymethylglutaryl-CoA reductase (NADPH)]-phosphate phosphohydrolase. This enzyme is also called reductase phosphatase.

References[edit]

  • Gil G, Hegardt FG (1982). "Some properties of purified 3-hydroxy-3-methylglutaryl coenzyme A reductase phosphatases from rat liver". Arch. Biochem. Biophys. 214 (1): 192–8. doi:10.1016/0003-9861(82)90022-4. PMID 6282220. 
  • Gil G, Sitges M, Hegardt FG (1981). "Purification and properties of rat liver hydroxymethylglutaryl coenzyme A reductase phosphatases". Biochim. Biophys. Acta. 663 (1): 211–21. doi:10.1016/0005-2760(81)90207-1. PMID 6260210.