Protein phosphatase methylesterase-1

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Protein phosphatase methylesterase-1
Identifiers
EC number 3.1.1.89
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

Protein phosphatase methylesterase-1 (EC 3.1.1.89, PME-1, PPME1) is an enzyme with systematic name (phosphatase 2A protein)-leucine ester acylhydrolase.[1][2] This enzyme catalyses the following chemical reaction

[phosphatase 2A protein]-leucine methyl ester + H2O [phosphatase 2A protein]-leucine + methanol

A key regulator of protein phosphatase 2A.

References[edit]

  1. ^ Ogris, E.; Du, X.; Nelson, K.C.; Mak, E.K.; Yu, X.X.; Lane, W.S.; Pallas, D.C. (1999). "A protein phosphatase methylesterase (PME-1) is one of several novel proteins stably associating with two inactive mutants of protein phosphatase 2A". J. Biol. Chem. 274 (20): 14382–14391. doi:10.1074/jbc.274.20.14382. PMC 3503312Freely accessible. PMID 10318862. 
  2. ^ Xing, Y.; Li, Z.; Chen, Y.; Stock, J.B.; Jeffrey, P.D.; Shi, Y. (2008). "Structural mechanism of demethylation and inactivation of protein phosphatase 2A". Cell. 133 (1): 154–163. doi:10.1016/j.cell.2008.02.041. PMID 18394995. 

External links[edit]