(protein-PII) uridylyltransferase

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[protein-PII] uridylyltransferase
EC number2.7.7.59
CAS number57657-57-5
IntEnzIntEnz view
ExPASyNiceZyme view
MetaCycmetabolic pathway
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO

In enzymology, a [protein-PII] uridylyltransferase (EC is an enzyme that catalyzes the chemical reaction

UTP + [protein-PII] diphosphate + uridylyl-[protein-PII]

Thus, the two substrates of this enzyme are UTP and protein-PII, whereas its two products are diphosphate and [[uridylyl-[protein-PII]]].

This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing nucleotide groups (nucleotidyltransferases). The systematic name of this enzyme class is UTP:[protein-PII] uridylyltransferase. Other names in common use include PII uridylyl-transferase, and uridyl removing enzyme. This enzyme participates in two-component system - general.


  • Garcia E, Rhee SG (1983). "Cascade control of Escherichia coli glutamine synthetase Purification and properties of PII uridylyltransferase and uridylyl-removing enzyme". J. Biol. Chem. 258 (4): 2246&ndash, 53. PMID 6130097.
  • van Heeswijk WC, Rabenberg M, Westerhoff HV, Kahn D (1993). "The genes of the glutamine synthetase adenylylation cascade are not regulated by nitrogen in Escherichia coli". Mol. Microbiol. 9 (3): 443&ndash, 57. doi:10.1111/j.1365-2958.1993.tb01706.x. PMID 8412694.