Enzyme-thiol transhydrogenase (glutathione-disulfide)

From Wikipedia, the free encyclopedia
Jump to: navigation, search
enzyme-thiol transhydrogenase (glutathione-disulfide)
Identifiers
EC number 1.8.4.7
CAS number 85030-79-1
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / QuickGO

In enzymology, an enzyme-thiol transhydrogenase (glutathione-disulfide) (EC 1.8.4.7) is an enzyme that catalyzes the chemical reaction

[xanthine dehydrogenase] + glutathione disulfide [xanthine oxidase] + 2 glutathione

Thus, the two substrates of this enzyme are xanthine dehydrogenase and glutathione disulfide, whereas its two products are xanthine oxidase and glutathione.

This enzyme belongs to the family of oxidoreductases, specifically those acting on a sulfur group of donors with a disulfide as acceptor. The systematic name of this enzyme class is [xanthine-dehydrogenase]:glutathione-disulfide S-oxidoreductase. Other names in common use include [xanthine-dehydrogenase]:oxidized-glutathione S-oxidoreductase, enzyme-thiol transhydrogenase (oxidized-glutathione), glutathione-dependent thiol:disulfide oxidoreductase, and thiol:disulfide oxidoreductase. This enzyme participates in glutathione metabolism.

References[edit]