Mannosyl-oligosaccharide 1,2-alpha-mannosidase

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Mannosyl-oligosaccharide 1,2-alpha-mannosidase
Identifiers
EC number 3.2.1.113
CAS number 9068-25-1
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

Mannosyl-oligosaccharide 1,2-alpha-mannosidase (EC 3.2.1.113, mannosidase 1A, mannosidase 1B, 1,2-alpha-mannosidase, exo-alpha-1,2-mannanase, mannose-9 processing alpha-mannosidase, glycoprotein processing mannosidase I, mannosidase I, Man9-mannosidase, ManI, 1,2-alpha-mannosyl-oligosaccharide alpha-D-mannohydrolase) is an enzyme with systematic name 2-alpha-mannosyl-oligosaccharide alpha-D-mannohydrolase.[1][2] This enzyme catalyses the following chemical reaction

Hydrolysis of the terminal (1->2)-linked alpha-D-mannose residues in the oligo-mannose oligosaccharide Man9(GlcNAc)2

This enzyme is involved in the synthesis of glycoproteins.

Kifunensine is a potent inhibitor of mannosidase I.

References[edit]

  1. ^ Tabas, I.; Kornfeld, S. (1979). "Purification and characterization of a rat liver Golgi α-mannosidase capable of processing asparagine-linked oligosaccharides". J. Biol. Chem. 254: 11655–11663. PMID 500665. 
  2. ^ Tulsiani, D.R.P; Hubbard, S.C.; Robbins, P.W.; Touster, O. (1982). "α-D-Mannosidases of rat liver Golgi membranes. Mannosidase II is the GlcNAcMAN5-cleaving enzyme in glycoprotein biosynthesis and mannosidases IA and IB are the enzymes converting Man9 precursors to Man5 intermediates". J. Biol. Chem. 257: 3660–3668. PMID 7061502. 

External links[edit]